Healthy blood microcirculation provides the essential nutrients and hydration that create the glow associated with youthful skin and is an essential factor in fighting skin aging. Powerful Beauty inspires optimal blood flow by generating endothelial nitric oxide (NO) which is the key mediator facilitating arterial relaxation, maximizing nutrient delivery and skin hydration.
Powerful Beauty nutrients selectively bind with collagen and elastin, helping rebuild and protect elastic tissue proteins and stimulate genesis of new collagen for a smooth, face firming effect The Powerful formula also increases hyaluronic acid production, moistening skin from the inside out, building volume and structure, and helping create plumper, younger looking skin.
The unique Powerful Beauty formula addresses multiple skin factors simultaneously for comprehensive skin enhancement and protection.
The benefits of Powerful Beauty go beyond incredible skin. Explore the data on how this formula addresses multiple health factors while enhancing and protecting a beautiful complexion.
Pycnogenol® shows pigmentation reduction in human skin.
Leis Ayres E, Costa A, Eberlin S, Platto Clerici S
Ex vivo study for evaluating the whitening activity of Pycnogenol® after exposure to ultraviolet and infrared radiations, and visible lights.
Surg Cosmet Dermatol 7: 303-307, 2015
CLINICAL STUDY: This article reviews earlier clinical Pycnogenol® research of the group, identifying improved skin elasticity and hydration, highlighting new findings on oral Pycnogenol® supporting fairer skin complexion, as well as improved skin barrier function.
Grether-Beck S, Marini A, Jaenicke T, Krutmann J
French Maritime Pine Bark Extract (Pycnogenol®) Effects on Human Skin: Clinical and Molecular Evidence.
Skin Pharmacol Physiol 29: 13-17, 2016
CLINICAL STUDY: The study describes significant reduction of skin pigmentation with Pycnogenol® supplementation, taken in addition to the use of sun-screens, in 31 women with melasma.
Scharf Pinto CA, Zuchi Delfes MF, Montanheiro dos Reis L, Garbers LE, Vieira da Rosa Passos PC, Skusa de Torre D The use of Pycnogenol® in the treatment of melasma.
Surg Cosmet Dermatol 7: 218-222, 2015
CLINICAL STUDY: Research demonstrates that Pycnogenol® in combination with pomegranate extract brightens skin and helps decrease blotches in European and and Asian women.
De Schuyteneer A, Hamon I, Rohdewald P
A formulation of extracts from pine bark and pomegranate improves complexion after oral intake.
Esperienze Dermatologiche 17: 7-11, 2015
CLINICAL STUDY: The oral administration of Pycnogenol® combined with daily sunscreen application should be added as an adjuvant to other treatments of melasma.
Oral administration of Pycnogenol® associated with sunscreen improve clinical symtpoms of melasma.
J Am Acad Dermatol AB19 (P8471), 2014
CLINICAL STUDY: Most common clinical aspects of psoriasis could be improved by Pycnogenol® supplementation.
Belcaro G, Luzzi R, Hu S, Cesarone MR, Dugall M, Ippolito E, Corsi M, Caporale S
Improvement in signs and symptoms in psoriasis patients with Pycnogenol® supplementation.
Panminerva Med 56: 41-48, 2014
CLINICAL STUDY: Pycnogenol® increases women’s skin elasticity and hydration which coincides with significantly new collagen and hyaluronic acid synthesis in their skin.
Marini A, Grether-Beck S, Jaenicke T, Weber M, Burki C, Formann P, Brenden H, Schönlau F, Krutmann J
Pycnogenol® Effects on Skin Elasticity and Hydration Coincide with Increased Gene Expressions of Collagen Type I and Hyaluronic Acid Synthase in Women.
Skin Pharmacol Physiol 25: 86-92, 2012
Pycnogenol® inhibits pigment formation in skin cells four times more potently than kojic acid, a compound commonly used in skin-whitening products.
Kim YJ, Kang KS, Yokozawa T
The anti-melanogenic effect of Pycnogenol® by its anti-oxidative actions.
Food and Chemical Toxicol 46: 2466-2471, 2008
Beneficial effects of Pycnogenol® in wrinkles- A review article.
Rona C, Vailati F, Berardesca E
The cosmetic treatment of wrinkles.
J Cosmet Dermatol 3: 26-34, 2004
CLINICAL STUDY: Pycnogenol® accelerates healing of diabetic ulcers in humans.
Belcaro G, Cesarone MR, Errichi BM, Ledda A, Di Renzo A, Stuard S, Dugall M, Pellegrini L, Gizzi G, Rohdewald P, Ippolito E, Ricci A, Cacchio M, Cipollone G, Ruffini I, Fano F, Hosoi M
Diabetic Ulcers: Microcirculatory Improvement and Faster Healing with Pycnogenol®.
Clin Appl Thromb Hemost 12: 318-323, 2006
Oral administration of Pycnogenol® is able to delay and to reduce skin cancer following UV radiation.
Kyriazi M, Yova D, Rallis M, Lima A
Cancer chemopreventive effects of Pinus maritima bark extract on ultraviolet radiation and ultraviolet radiation-7,12 dimethylbenz(a) anthracene induced skin carcinogenesis of hairless mice.
Cancer Lett 237: 234-241, 2006
CLINICAL STUDY: Pycnogenol® inhibits release of enzymes involved in breaking-down collagen and elastin in inflamed skin in humans.
Grimm T, Chovanova Z, Muchova J, Sumegova K, Liptakova A, Durackova Z, Högger P
Inhibition of NF-kappaB activation and MMP-9 secretion by plasma of human volunteers after ingestion of maritime pine bark extract (Pycnogenol®).
J Inflamm 3: 1-6, 2006
CLINICAL STUDY: Ulcers of the lower legs heal faster with orally and topically applied Pycnogenol®.
Belcaro G, Cesarone MR, Errichi BM, Ledda A, Di Renzo A, Stuard S, Dugall M, Pellegrini L, Rohdewald P, Ippolito E, Ricci A, Cacchio M, Ruffini I, Fano F, Hosoi M
Venous Ulcers: Microcirculatory Improvement and Faster Healing with Local Use of Pycnogenol®.
Angiology 56: 699-705, 2005
Pycnogenol® shows antimicrobial activity at very low concentration.
Torras MAC, Faura CA, Schönlau F, Rohdewald P Anti-microbial activity of Pycnogenol®.
Phytother Res 19: 647-648, 2005
Evidence of percutaneous absorption of Pycnogenol® in human skin.
Sarikaki V, Rallis M, Tanojo H, Panteri I, Dotsikas Y, Loukas YL, Papaioannou G, Demetzos C, Weber S, Moini H, Maibach HI, Packer L
In vitro percutaneous absorption of pine bark extract (Pycnogenol®) in human skin.
J Toxicol Cutaneous Ocul Toxicol 23: 149-158, 2004
Topically applied Pycnogenol® dose-dependently speeds-up the wound healing process and reduces scar formation.
Blazso G, Gabor M, Schönlau F, Rohdewald P
Pycnogenol® accelerates wound healing and reduces scar formation.
Phytother Res 18: 579-581, 2004
CLINICAL STUDY: Supplementation with Pycnogenol® in combination with vitamins, minerals improves skin smoothness and elasticity in women.
Segger D, Schönlau F
Supplementation with Evelle® improves smoothness and elasticity in a double blind, placebo- controlled study with 62 women.
J Dermatolog Treat 15: 222-226, 2004
Pycnogenol® applied topically after sunburn inhibits photocarcinogenesis.
Sime S, Reeve VE
Protection from inflammation, immunosuppression and carcinogenesis induced by UV radiation in mice by topical Pycnogenol®.
Photochem Photobiol 79: 193-198, 2004
CLINICAL STUDY: The collagen and elastin destroying enzymes are potently inhibited by Pycnogenol® as well as its metabolites prevailing in humans after oral consumption.
Grimm T, Schäfer A, Högger P
Antioxidant activity and inhibition of matrix metalloproteinases by metabolites of maritime pine bark extract (Pycnogenol®).
J Free Radic Biol Med 36: 811-822, 2004
Review summarizing the beneficial effects of Pycnogenol® for skin care.
The cosmeceutical Pycnogenol®.
J Appl Cosmetol 20: 241-246, 2002
CLINICAL STUDY: Pycnogenol® counteracts skin hyper-pigmentation in women.
Ni Z, Mu Y, Gulati O
Treatment of melasma with Pycnogenol®.
Phytother Res 16: 567-571, 2002
CLINICAL STUDY: Pycnogenol® dose-dependently inhibits UV-induced erythema in humans, demonstrating a potent anti-photoageing effect.
Saliou C, Rimbach G, Moini H, McLaughlin L, Hosseini S, Lee J, Watson RR, Packer L
Solar ultraviolet-induced erythema in human skin and nuclear factor-kappa-B-dependent gene expression in keratinocytes are modulated by French maritime pine bark extract.
J Free Radic Biol Med 30: 154-160, 2001
Pycnogenol® favourably affects the gene expression profile in human keratinocytes, indicating a promising potential for improving inflammatory skin disorders such as psoriasis and dermatoses.
Rihn B, Saliou C, Bottin MC, Keith G, Packer L
From ancient remedies to modern therapeutics: Pine bark uses in skin disorders revisited.
Phytother Res 15: 76-78, 2001
Pycnogenol® inhibits the production of adhesion molecules in human skin cells during inflammation which would contribute to relieving inflammatory skin disorders.
Bito T, Roy S, Sen CK, Packer L
Pine bark extract Pycnogenol® down regulates IFN-γ - induced adhesion of T cells to human keratinocytes by inhibiting inducible ICAM-1 expression.
J Free Radic Biol Med 28: 219-227, 2000
Pycnogenol® prolongs the lifetime of vitamin C which will contribute to higher vitamin C presence in the skin.
Cossins E, Lee R, Packer L
ESR studies of vitamin C regeneration, order of reactivity of natural source phytochemical preparations.
Biochem Mol Biol Int 45: 583-597, 1998
Pycnogenol® protects α-tocopherol from oxidation and extends its life-time in endothelial cells.
Virgili F, Kim D, Packer L
Procyanidins extracted from pine bark protect α-tocopherol in ECV 304 endothelial cells challenged by activated RAW 264.7 macrophages: role of nitric oxide peroxynitrite.
FEBS Lett 431: 315-318, 1998
Pycnogenol® produces an anti-oedema effect in two different models. Topical application of Pycnogenol® gel protects the skin against UV radiation.
Blazso G, Gabor M, Rohdewald P
Anti-inflammatory activities of procyanidin containing extracts from Pinus pinaster Ait. after oral and cutaneous application.
Pharmazie 52: 380-382, 1997
Pycnogenol® increases pathologically low capillary wall resistance. Pycnogenol® is shown to be the most potent among other bioflavonoids tested. Pycnogenol® provides strength to capillary walls and makes them less permeable and thus contributes to anti-oedema, anti-inflammatory effects.
Gabor M, Engi E, Sonkodi S
Die Kapillarwandresistenz und ihre Beeinflussung durch wasserlösliche Flavonderivate bei spontan hypertonischen Ratten.
Phlebologie 22: 178-182, 1993
Pycnogenol® dose-dependently protects the skin from ultraviolet-radiation-induced oxidative stress injury (lipid peroxidation and cytotoxicity).
Ultraviolet radiation-induced oxidative stress in cultured human skin fibroblasts and antioxidant protection.
Bio Res Rep Univ Jyväskylä 33: 1-86, 1993