Powerful Beauty combines safe ingredients in effective doses to deliver proven enhancement and protection for exceptional skin.

Feed your skin.

Healthy blood microcirculation provides the essential nutrients and hydration that create the glow associated with youthful skin and is an essential factor in fighting skin aging. Powerful Beauty inspires optimal blood flow by generating endothelial nitric oxide (NO) which is the key mediator facilitating arterial relaxation, maximizing nutrient delivery and skin hydration.

CAPILLARY MICROCIRCULATION

Fight wrinkles.

Powerful Beauty nutrients selectively bind with collagen and elastin, helping rebuild and protect elastic tissue proteins and stimulate genesis of new collagen for a smooth, face firming effect. The Powerful formula also increases hyaluronic acid production, moistening skin from the inside out, building volume and structure, and helping create plumper, younger looking skin.

elastic tissue degeneration

The Numbers.

The unique Powerful Beauty formula addresses multiple skin factors simultaneously for comprehensive skin enhancement and protection.

pigmentation intensity reduction

pigmentation intensity reduction

increased uv exposure resistance

increased uv exposure resistance

collagen and elastin synthesis

collagen and elastin synthesis

hyaluronic acid synthesis

hyaluronic acid synthesis

improved skin respiration

improved skin respiration

Research.

The benefits of Powerful Beauty go beyond incredible skin. Explore the data on how this formula addresses multiple health factors while enhancing and protecting a beautiful complexion.

Pycnogenol® shows pigmentation reduction in human skin.

Leis Ayres E, Costa A, Eberlin S, Platto Clerici S

Ex vivo study for evaluating the whitening activity of Pycnogenol® after exposure to ultraviolet and infrared radiations, and visible lights.

Surg Cosmet Dermatol 7: 303-307, 2015

 

CLINICAL STUDY: This article reviews earlier clinical Pycnogenol® research of the group, identifying improved skin elasticity and hydration, highlighting new findings on oral Pycnogenol® supporting fairer skin complexion, as well as improved skin barrier function.

Grether-Beck S, Marini A, Jaenicke T, Krutmann J

French Maritime Pine Bark Extract (Pycnogenol®) Effects on Human Skin: Clinical and Molecular Evidence.

Skin Pharmacol Physiol 29: 13-17, 2016

 

CLINICAL STUDY: The study describes significant reduction of skin pigmentation with Pycnogenol® supplementation, taken in addition to the use of sun-screens, in 31 women with melasma.

Scharf Pinto CA, Zuchi Delfes MF, Montanheiro dos Reis L, Garbers LE, Vieira da Rosa Passos PC, Skusa de Torre D The use of Pycnogenol® in the treatment of melasma.

Surg Cosmet Dermatol 7: 218-222, 2015

 

CLINICAL STUDY: Research demonstrates that Pycnogenol® in combination with pomegranate extract brightens skin and helps decrease blotches in European and and Asian women.

De Schuyteneer A, Hamon I, Rohdewald P

A formulation of extracts from pine bark and pomegranate improves complexion after oral intake.

Esperienze Dermatologiche 17: 7-11, 2015

 

CLINICAL STUDY: The oral administration of Pycnogenol® combined with daily sunscreen application should be added as an adjuvant to other treatments of melasma.

Campos V

Oral administration of Pycnogenol® associated with sunscreen improve clinical symtpoms of melasma.

J Am Acad Dermatol AB19 (P8471), 2014

 

CLINICAL STUDY: Most common clinical aspects of psoriasis could be improved by Pycnogenol® supplementation.

Belcaro G, Luzzi R, Hu S, Cesarone MR, Dugall M, Ippolito E, Corsi M, Caporale S

Improvement in signs and symptoms in psoriasis patients with Pycnogenol® supplementation.

Panminerva Med 56: 41-48, 2014

 

CLINICAL STUDY: Pycnogenol® increases women’s skin elasticity and hydration which coincides with significantly new collagen and hyaluronic acid synthesis in their skin.

Marini A, Grether-Beck S, Jaenicke T, Weber M, Burki C, Formann P, Brenden H, Schönlau F, Krutmann J

Pycnogenol® Effects on Skin Elasticity and Hydration Coincide with Increased Gene Expressions of Collagen Type I and Hyaluronic Acid Synthase in Women.

Skin Pharmacol Physiol 25: 86-92, 2012

 

Pycnogenol® inhibits pigment formation in skin cells four times more potently than kojic acid, a compound commonly used in skin-whitening products.

Kim YJ, Kang KS, Yokozawa T

The anti-melanogenic effect of Pycnogenol® by its anti-oxidative actions.

Food and Chemical Toxicol 46: 2466-2471, 2008

 

Beneficial effects of Pycnogenol® in wrinkles- A review article.

Rona C, Vailati F, Berardesca E

The cosmetic treatment of wrinkles.

J Cosmet Dermatol 3: 26-34, 2004

 

CLINICAL STUDY: Pycnogenol® accelerates healing of diabetic ulcers in humans.

Belcaro G, Cesarone MR, Errichi BM, Ledda A, Di Renzo A, Stuard S, Dugall M, Pellegrini L, Gizzi G, Rohdewald P, Ippolito E, Ricci A, Cacchio M, Cipollone G, Ruffini I, Fano F, Hosoi M

Diabetic Ulcers: Microcirculatory Improvement and Faster Healing with Pycnogenol®.

Clin Appl Thromb Hemost 12: 318-323, 2006

 

Oral administration of Pycnogenol® is able to delay and to reduce skin cancer following UV radiation.

Kyriazi M, Yova D, Rallis M, Lima A

Cancer chemopreventive effects of Pinus maritima bark extract on ultraviolet radiation and ultraviolet radiation-7,12 dimethylbenz(a) anthracene induced skin carcinogenesis of hairless mice.

Cancer Lett 237: 234-241, 2006

 

CLINICAL STUDY: Pycnogenol® inhibits release of enzymes involved in breaking-down collagen and elastin in inflamed skin in humans.

Grimm T, Chovanova Z, Muchova J, Sumegova K, Liptakova A, Durackova Z, Högger P

Inhibition of NF-kappaB activation and MMP-9 secretion by plasma of human volunteers after ingestion of maritime pine bark extract (Pycnogenol®).

J Inflamm 3: 1-6, 2006

 

CLINICAL STUDY: Ulcers of the lower legs heal faster with orally and topically applied Pycnogenol®.

Belcaro G, Cesarone MR, Errichi BM, Ledda A, Di Renzo A, Stuard S, Dugall M, Pellegrini L, Rohdewald P, Ippolito E, Ricci A, Cacchio M, Ruffini I, Fano F, Hosoi M

Venous Ulcers: Microcirculatory Improvement and Faster Healing with Local Use of Pycnogenol®.

Angiology 56: 699-705, 2005

 

Pycnogenol® shows antimicrobial activity at very low concentration.

Torras MAC, Faura CA, Schönlau F, Rohdewald P Anti-microbial activity of Pycnogenol®.

Phytother Res 19: 647-648, 2005

 

Evidence of percutaneous absorption of Pycnogenol® in human skin.

Sarikaki V, Rallis M, Tanojo H, Panteri I, Dotsikas Y, Loukas YL, Papaioannou G, Demetzos C, Weber S, Moini H, Maibach HI, Packer L

In vitro percutaneous absorption of pine bark extract (Pycnogenol®) in human skin.

J Toxicol Cutaneous Ocul Toxicol 23: 149-158, 2004

 

Topically applied Pycnogenol® dose-dependently speeds-up the wound healing process and reduces scar formation.

Blazso G, Gabor M, Schönlau F, Rohdewald P

Pycnogenol® accelerates wound healing and reduces scar formation.

Phytother Res 18: 579-581, 2004

 

CLINICAL STUDY: Supplementation with Pycnogenol® in combination with vitamins, minerals improves skin smoothness and elasticity in women.

Segger D, Schönlau F

Supplementation with Evelle® improves smoothness and elasticity in a double blind, placebo- controlled study with 62 women.

J Dermatolog Treat 15: 222-226, 2004

 

Pycnogenol® applied topically after sunburn inhibits photocarcinogenesis.

Sime S, Reeve VE

Protection from inflammation, immunosuppression and carcinogenesis induced by UV radiation in mice by topical Pycnogenol®.

Photochem Photobiol 79: 193-198, 2004

 

CLINICAL STUDY: The collagen and elastin destroying enzymes are potently inhibited by Pycnogenol® as well as its metabolites prevailing in humans after oral consumption.

Grimm T, Schäfer A, Högger P

Antioxidant activity and inhibition of matrix metalloproteinases by metabolites of maritime pine bark extract (Pycnogenol®).

J Free Radic Biol Med 36: 811-822, 2004

 

Review summarizing the beneficial effects of Pycnogenol® for skin care.

Schönlau F

The cosmeceutical Pycnogenol®.

J Appl Cosmetol 20: 241-246, 2002

 

CLINICAL STUDY: Pycnogenol® counteracts skin hyper-pigmentation in women.

Ni Z, Mu Y, Gulati O

Treatment of melasma with Pycnogenol®.

Phytother Res 16: 567-571, 2002

 

CLINICAL STUDY: Pycnogenol® dose-dependently inhibits UV-induced erythema in humans, demonstrating a potent anti-photoageing effect.

Saliou C, Rimbach G, Moini H, McLaughlin L, Hosseini S, Lee J, Watson RR, Packer L

Solar ultraviolet-induced erythema in human skin and nuclear factor-kappa-B-dependent gene expression in keratinocytes are modulated by French maritime pine bark extract.

J Free Radic Biol Med 30: 154-160, 2001

 

Pycnogenol® favourably affects the gene expression profile in human keratinocytes, indicating a promising potential for improving inflammatory skin disorders such as psoriasis and dermatoses.

Rihn B, Saliou C, Bottin MC, Keith G, Packer L

From ancient remedies to modern therapeutics: Pine bark uses in skin disorders revisited.

Phytother Res 15: 76-78, 2001

 

Pycnogenol® inhibits the production of adhesion molecules in human skin cells during inflammation which would contribute to relieving inflammatory skin disorders.

Bito T, Roy S, Sen CK, Packer L

Pine bark extract Pycnogenol® down regulates IFN-γ - induced adhesion of T cells to human keratinocytes by inhibiting inducible ICAM-1 expression.

J Free Radic Biol Med 28: 219-227, 2000

 

Pycnogenol® prolongs the lifetime of vitamin C which will contribute to higher vitamin C presence in the skin.

Cossins E, Lee R, Packer L

ESR studies of vitamin C regeneration, order of reactivity of natural source phytochemical preparations.

Biochem Mol Biol Int 45: 583-597, 1998

 

Pycnogenol® protects α-tocopherol from oxidation and extends its life-time in endothelial cells.

Virgili F, Kim D, Packer L

Procyanidins extracted from pine bark protect α-tocopherol in ECV 304 endothelial cells challenged by activated RAW 264.7 macrophages: role of nitric oxide peroxynitrite.

FEBS Lett 431: 315-318, 1998

 

Pycnogenol® produces an anti-oedema effect in two different models. Topical application of Pycnogenol® gel protects the skin against UV radiation.

Blazso G, Gabor M, Rohdewald P

Anti-inflammatory activities of procyanidin containing extracts from Pinus pinaster Ait. after oral and cutaneous application.

Pharmazie 52: 380-382, 1997

 

Pycnogenol® increases pathologically low capillary wall resistance. Pycnogenol® is shown to be the most potent among other bioflavonoids tested. Pycnogenol® provides strength to capillary walls and makes them less permeable and thus contributes to anti-oedema, anti-inflammatory effects.

Gabor M, Engi E, Sonkodi S

Die Kapillarwandresistenz und ihre Beeinflussung durch wasserlösliche Flavonderivate bei spontan hypertonischen Ratten.

Phlebologie 22: 178-182, 1993

 

Pycnogenol® dose-dependently protects the skin from ultraviolet-radiation-induced oxidative stress injury (lipid peroxidation and cytotoxicity).

Guochang Z

Ultraviolet radiation-induced oxidative stress in cultured human skin fibroblasts and antioxidant protection.

Bio Res Rep Univ Jyväskylä 33: 1-86, 1993

Start your journey.

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Here’s to your beauty and wellbeing!

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Powerful Beauty Reviews

five star review
"From previous acne scarring, exposure to the sun and free radical damage, one of my biggest concerns is an even complexion. I added Powerful to my skin care regime and can visibly see a reduction in hyperpigmentation spots, smoother texture and more glow, and others have noticed as well! I highly recommend adding this tool to your daily routine."

Aubrey W.
five star review
"I've been using Powerful for over a year and I love what it does for my skin. I travel frequently, and changing environments used to create complexion challenges. With Powerful that's no longer a problem and I always have it with me."

Kristin A.
five star review
"I take my skin care seriously. After adding Powerful to my regimen I became a longtime user and I feel like I am aging in reverse. Not only are the skin benefits undeniable, my workouts and focus are incredible."

Kristina M.
five star review
"I use the best skin care products money can buy, but Powerful has taken my skin to the next level. Adding internal help to my topical routine has produced results."

Susan B.
five star review
"I rely on Powerful to help protect my skin from dangerous UV rays and fight free radicals from pollutants and the California smog. It also improves my workouts, boosts my overall health, and fights skin aging."

Keara M.
five star review
"I have seen very impressive results with my clients who have been using Powerful regularly and their skin continues to improve. This is the only product I have seen make good on lightening persistent age spots and sun damage that is not responsive to IPL, peels or other surface treatments."

Carla B.
Master Esthetician
five star review
"Powerful has dramatically changed the tone of my skin in just one month. It evens out pigmentation, boosts firmness, and I've noticed a big difference in the way my skin glows by adding this to my regimen. I highly recommend it."

Sophie M.
five star review
"I Absolutely love Powerful. I have taken it for two years and have seen so many benefits. Keep it coming. Thank you Advanced Biology!"

Joel T.
five star review
My skin feels great and has a healthy glow. Also: My fingernails used to break all the time, but now they don’t at all, and they are growing faster than they ever have!"

Angie H.
five star review
Love it so. My skin feels amazing after using this product! Well worth incorporating into a skin care regiment

Mirabella H.
five star review
Two weeks and my skin already looks and feels healthier!

Michael B.
five star review
My hyperpigmentation has faded and I have a pink glow again. I absolutely love it!

Skin J.
five star review
I'm feeling this supplement. My dark spots seem smaller and lighter and my skin definitely feels plumper. So far, so good!

Deana F.

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