Real clinical trial and study data.

We take our science seriously, that’s why Powerful Beauty is backed by published trials and studies verifying the effectiveness of our formula and nutrients. Explore findings by researchers all over the world that support our claims.

Romero M, Platt D, Caldwell RB, Caldwell RW. Therapeutic Use of Citrulline in Cardiovascular Disease. Cardiovascular Drug Reviews November 2006.

Neek L, Gaeini A, Choobineh S. Effect of Zinc and Selenium Supplementation on Serum Testosterone and Plasma Lactate in Cyclist After an Exhaustive Exercise Bout. Biological Trace Element Research. July 2011. Published Ahead of Print.

Vinciguerra G, Belcaro G, Bonanni E, Cesarone MR, Rotondi V, Ledda A, Hosoi M, Dugall M, Cacchio M, Cornelli U. Evaluation of the Effects of supplementation with Pycnogenol® on Fitness in Normal Subjects with the Army Physical Fitness Test and in Performances of Athletes in the 100-Minute Triathlon. The Journal of Sports Medicine and Physical Fitness. December 2013.

Vinciguerra G, Belcaro G, Cesarone MR, Rohdewald P, Stuard S, Ricci A, Di Renzo A, Hosoi M, Dugall M, Ledda A, Cacchio M, Acerbi G, Fano F. Cramps and Muscular Pain: Prevention with Pycnogenol® in Normal Subjects, Venous Patients, Athletes, Claudicants and in Diabetic Microangiopathy. Angiology. May 2006.

Marini A, Grether-Beck S, Jaenicke T, Weber M, Burki C, Formann P, Brenden H, Schönlau F, Krutmann J. Effects on Skin Elasticity and Hydration Coincide with Increased Gene Expressions of Collagen Type I and Hyaluronic Acid Synthase in Women. Skin Pharmacology and Physiology. January 2012.

Saliou C, Rimbach G, Moini H, McLaughlin L, Hosseini S, Lee J, Watson RR, Packer L. Solar Ultraviolet-Induced Erythema in Human Skin and NF-KappaB Dependent Gene Expression in Keratinocytes are Modulated by a French Maritime Pine Bark Extract. Free Radicical Biology and Medicine. January 2001.

Grimm T, Chovanová Z, Muchová J, Sumegová K, Liptáková A, Duracková Z, Högger P. Inhibition of NF-kappaB Activation and MMP-9 Secretion by Plasma of Human Volunteers After Ingestion of Maritime Pine Bark Extract (Pycnogenol®). Journal of Inflammation. January 2006.

Kim Y, Kang K, Yokozawa T. The Anti-Melanogenic Effect of Pycnogenol® by its Anti-Oxidative Actions. Food and Chemical Toxicology. April 2008.

Grether-Beck S, Marini A, Jaenicke T, Krutmann J. French Maritime Pine Bark Extract (Pycnogenol®) Effects on Human Skin: Clinical and Molecular Evidence. Skin Pharmacology and Physiology. October 2015.

Ni Z, Mu Y, Gulati O. Treatment of Melasma with Pycnogenol®. Phytotherapy Research. September 2002.

Fitzpatrick D, Bing B, Rohdewald P. Endothelium-Dependent Vascular Effects of Pycnogenol®. Journal of Cardiovascular Pharmacology. October 1998.

Belcaro G, Cesarone M, Errichi B, Ledda A, Di Renzo A, Stuard S, Dugall M, Pellegrini L, Gizzi G, Rohdewald P, Ippolito E, Ricci A, Cacchio M, Cipollone G, Ruffini I, Fano F, Hosoi M. Diabetic Ulcers: Microcirculatory Improvement and Faster Healing with Pycnogenol®. Clinical and Applied Thrombosis/Hemostasis July 2006.

Kuhn K, Harris P, Cunningham G, Robbins I, Summar M, Christman B. Oral Citrulline Effectively Elevates Plasma Arginine Levels for 24 Hours in Normal Volunteers. Circulation AHA Scientific Sessions. May 2006.

Rohdewald P. A Review of the French Maritime Pine Bark Extract Pycnogenol®, a Herbal Medication With a Diverse Pharmacology. The International Journal of Clinical Pharmacology and Therapeutics. April 2002.

Devaraj S, Vega-López S, Kaul N, Schönlau F, Rohdewald P, Jialal I. Supplementation With a Pine Bark Extract Rich in Polyphenols Increases Plasma Antioxidant Capacity and Alters the Plasma Lipoprotein Profile. Lipids. October 2002.

Hosseini S, Lee J, Sepulveda RT, Fagan T, Rohdewald P, Watson RR. A Randomized, Double Blind, Placebo Controlled, Prospective, 16 Week Crossover Study to Determine the Role of Pycnogenol® in Modifying Blood Pressure in Mildly Hypertensive Patients. Nutrition Research. September 2001.

Koch R. Comparative Study of Venostasin® and Pycnogenol® in Chronic Venous Insufficiency. Phytotherapy Research. March 2002.

Durackova Z, Trebaticky B, Novotny V, Zitnanova A, Breza J. Lipid Metabolism and Erectile Function Improvement by Pycnogenol®, Extract From the Bark of Pinus Pinaster in Patients Suffering From Erectile Dysfunction – A Pilot Study. Nutrition Research. September 2003.

Yang H, Liao M, Yuan Z, Liao M, Rohdewald P. A Randomized, Double-Blind, Placebo-Controlled Trial on the Effect of Pycnogenol® on the Climacteric Syndrome in Peri-Menopausal Women. Acta Obstetricia et Gynecologica Scandinavica. May 2007.

Zibadi S, Qianli Y, Rohdewald P, Larson D, Watson R. Impact of Pycnogenol® on Left Ventricular Remodeling Induced by L-NAME Administration. Cardiovascular Toxicology. April 2007.

Schäfer A, Högger P. Oligomeric Procyanidins of French Maritime Pine Bark Extract (Pycnogenol®) Effectively Inhibit Alpha-Glucosidase. Diabetes Research and Clinical Practice. August 2007.

Liu X, Zhou H, Rohdewald P. French Maritime Pine Bark Extract in Pycnogenol® Dose-Dependently Lowers Glucose in Type 2 Diabetic Patients. Diabetes Care. March 2004.

Belcaro G, Cornelli U, Luzzi R, Cesarone M, Dugall M, Feragalli B, Errichi S, Ippolito E, Grossi M, Hosoi M, Cornelli M, Gizzi G. Pycnogenol® Supplementation Improves Health Risk Factors in Subjects With Metabolic Syndrome. Phytotherapy Research. October 2013.

Zibadi S, Rohdewald P, Park D, Watson R. Reduction of Cardiovascular Risk Factors in Subjects With Type 2 Diabetes by Pycnogenol® Supplementation. Nutrition Research. April 2008.

Liu X, Wei J, Tan F, Zhou S, Würthwein G, Rohdewald P. Antidiabetic Effect of Pycnogenol® French Maritime Pine Bark Extract in Patients With Diabetes Type II. Life Sciences. October 2004.

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