Frequently Asked Questions

Answers to questions about Advanced Biology and the Powerful supplement.

About Advanced Biology.

Every Advanced Biology product is exclusively manufactured in GMP certified, FDA approved facilities in the USA.

From the harvesting of our ingredients to processing, transport, production and storage, we demand the best, and test at every stage of the process to confirm that what we sell you is exactly what we say it is. We use patented, guaranteed ingredients, and manufacture exclusively in GMP certified, FDA approved facilities in the USA.

Yes. We take your privacy and security seriously. We use industry standard Secure Sockets Layer (SSL) for the encryption of all financial and personal information you submit on our site. We do not store your credit card information on our servers, and we do not share your personal data with any third parties.

We take your privacy seriously. Visit the Privacy Policy page for an updated version of our privacy promise to you.

Visit the Terms of Service page for an updated version of our comprehensive terms of use.

All orders are shipped USPS Priority Mail. We ship Monday through Friday, and depending on your location, orders generally arrives in 1-3 business days. Orders placed before noon are shipped the same day. Shipping is free on orders over $100.00. We currently ship only in the Continental United States. Visit the Delivery and Return Policy page for more information.

We are located in Washington state, which requires us to charge 9.6% sales tax on purchases by Washington residents. No sales tax is charged on purchases by non-residents of Washington state.

Keep in mind that many of the advantages of using Powerful take 30 to 90 days of consistent use, so we recommend sticking with it. We have a simple process for processing returns, including first time customer used products, damaged or defective products, and original condition products at no cost to you within 30 days of delivery. Visit the Delivery and Return Policy page for more information.

We want you to have an excellent experience and we are here to help. If you have more questions, contact us by email at and we will get right back to you.

About Powerful.

There are many mechanisms of action at work when you use the Powerful formula. Check out the Powerful Science page to learn more.

Powerful contains only the highest quality, proven ingredients in effective doses. Visit the Powerful Ingredients page to learn more.

Absolutely. Every claim we make is based on numerous real human trials and studies by medical researchers, with peer reviewed data published by respected medical journals and organizations including the National Institute of Health. Check out the Trials and Studies below to learn more.

Powerful is a large pill, there’s no way around it. If you have a problem with large pills, they are scored so they may easily be broken in half. Whether or not you consume Powerful™ with food is a matter of what works best for you when taking supplements and has no bearing on efficacy. A small percentage of people that are not used to consuming arginine may experience a short period of stomach upset or loose stool, which can usually be avoided by building up to a full dose over the course of a week. This might be 1 pill once per day for 2 days, 1 pill twice per day for 2 days, 2 pills twice per day for two days, then 3 pills twice per day.
No. Powerful has not been shown to have any of the negative effects associated with many supplements. If you experience something beyond a short period of acclimating to a new supplement stop using it immediately. A small percentage of people that are not used to consuming arginine may experience a short period of stomach upset or loose stool, which can usually be avoided by building up to a full dose over the course of a week.

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Powerful is an incredibly effective vasodilator and when combined with certain medications for heart conditions, high blood pressure or erectile dysfunction may cause a sudden drop in blood pressure. If you suffer from cold sores or genital herpes Powerful may trigger the virus. Always consult a medical professional before starting a supplement as strong as Powerful.
We want you to have an excellent experience and we are here to help. If you have more questions, contact us by email at and we will get right back to you.

Trials and Studies.

We take our science seriously, that’s why our products are backed by published trials and studies verifying the effectiveness of our formulas and nutrients. Explore findings by researchers all over the world that support our claims.

1. Romero M, Platt D, Caldwell RB, Caldwell RW. Therapeutic Use of Citrulline in Cardiovascular Disease. Cardiovascular Drug Reviews November 2006.

2. Neek L, Gaeini A, Choobineh S. Effect of Zinc and Selenium Supplementation on Serum Testosterone and Plasma Lactate in Cyclist After an Exhaustive Exercise Bout. Biological Trace Element Research. July 2011. Published Ahead of Print.

3. Vinciguerra G, Belcaro G, Bonanni E, Cesarone MR, Rotondi V, Ledda A, Hosoi M, Dugall M, Cacchio M, Cornelli U. Evaluation of the Effects of supplementation with Pycnogenol® on Fitness in Normal Subjects with the Army Physical Fitness Test and in Performances of Athletes in the 100-Minute Triathlon. The Journal of Sports Medicine and Physical Fitness. December 2013.

4. Vinciguerra G, Belcaro G, Cesarone MR, Rohdewald P, Stuard S, Ricci A, Di Renzo A, Hosoi M, Dugall M, Ledda A, Cacchio M, Acerbi G, Fano F. Cramps and Muscular Pain: Prevention with Pycnogenol® in Normal Subjects, Venous Patients, Athletes, Claudicants and in Diabetic Microangiopathy. Angiology. May 2006.

5. Marini A, Grether-Beck S, Jaenicke T, Weber M, Burki C, Formann P, Brenden H, Schönlau F, Krutmann J. Effects on Skin Elasticity and Hydration Coincide with Increased Gene Expressions of Collagen Type I and Hyaluronic Acid Synthase in Women. Skin Pharmacology and Physiology. January 2012.

6. Saliou C, Rimbach G, Moini H, McLaughlin L, Hosseini S, Lee J, Watson RR, Packer L. Solar Ultraviolet-Induced Erythema in Human Skin and NF-KappaB Dependent Gene Expression in Keratinocytes are Modulated by a French Maritime Pine Bark Extract. Free Radicical Biology and Medicine. January 2001.

7. Grimm T, Chovanová Z, Muchová J, Sumegová K, Liptáková A, Duracková Z, Högger P. Inhibition of NF-kappaB Activation and MMP-9 Secretion by Plasma of Human Volunteers After Ingestion of Maritime Pine Bark Extract (Pycnogenol®). Journal of Inflammation. January 2006.

8. Kim Y, Kang K, Yokozawa T. The Anti-Melanogenic Effect of Pycnogenol® by its Anti-Oxidative Actions. Food and Chemical Toxicology. April 2008.

9. Grether-Beck S, Marini A, Jaenicke T, Krutmann J. French Maritime Pine Bark Extract (Pycnogenol®) Effects on Human Skin: Clinical and Molecular Evidence. Skin Pharmacology and Physiology. October 2015.

10. Ni Z, Mu Y, Gulati O. Treatment of Melasma with Pycnogenol®. Phytotherapy Research. September 2002.

11. Fitzpatrick D, Bing B, Rohdewald P. Endothelium-Dependent Vascular Effects of Pycnogenol®. Journal of Cardiovascular Pharmacology. October 1998.

12. Belcaro G, Cesarone M, Errichi B, Ledda A, Di Renzo A, Stuard S, Dugall M, Pellegrini L, Gizzi G, Rohdewald P, Ippolito E, Ricci A, Cacchio M, Cipollone G, Ruffini I, Fano F, Hosoi M. Diabetic Ulcers: Microcirculatory Improvement and Faster Healing with Pycnogenol®. Clinical and Applied Thrombosis/Hemostasis July 2006.

13. Kuhn K, Harris P, Cunningham G, Robbins I, Summar M, Christman B. Oral Citrulline Effectively Elevates Plasma Arginine Levels for 24 Hours in Normal Volunteers. Circulation AHA Scientific Sessions. May 2006.

14. Rohdewald P. A Review of the French Maritime Pine Bark Extract Pycnogenol®, a Herbal Medication With a Diverse Pharmacology. The International Journal of Clinical Pharmacology and Therapeutics. April 2002.

15. Devaraj S, Vega-López S, Kaul N, Schönlau F, Rohdewald P, Jialal I. Supplementation With a Pine Bark Extract Rich in Polyphenols Increases Plasma Antioxidant Capacity and Alters the Plasma Lipoprotein Profile. Lipids. October 2002.

16. Hosseini S, Lee J, Sepulveda RT, Fagan T, Rohdewald P, Watson RR. A Randomized, Double Blind, Placebo Controlled, Prospective, 16 Week Crossover Study to Determine the Role of Pycnogenol® in Modifying Blood Pressure in Mildly Hypertensive Patients. Nutrition Research. September 2001.

17. Koch R. Comparative Study of Venostasin® and Pycnogenol® in Chronic Venous Insufficiency. Phytotherapy Research. March 2002.

18. Durackova Z, Trebaticky B, Novotny V, Zitnanova A, Breza J. Lipid Metabolism and Erectile Function Improvement by Pycnogenol®, Extract From the Bark of Pinus Pinaster in Patients Suffering From Erectile Dysfunction – A Pilot Study. Nutrition Research. September 2003.

19. Yang H, Liao M, Yuan Z, Liao M, Rohdewald P. A Randomized, Double-Blind, Placebo-Controlled Trial on the Effect of Pycnogenol® on the Climacteric Syndrome in Peri-Menopausal Women. Acta Obstetricia et Gynecologica Scandinavica. May 2007.

20. Zibadi S, Qianli Y, Rohdewald P, Larson D, Watson R. Impact of Pycnogenol® on Left Ventricular Remodeling Induced by L-NAME Administration. Cardiovascular Toxicology. April 2007.

21. Schäfer A, Högger P. Oligomeric Procyanidins of French Maritime Pine Bark Extract (Pycnogenol®) Effectively Inhibit Alpha-Glucosidase. Diabetes Research and Clinical Practice. August 2007.

22. Liu X, Zhou H, Rohdewald P. French Maritime Pine Bark Extract in Pycnogenol® Dose-Dependently Lowers Glucose in Type 2 Diabetic Patients. Diabetes Care. March 2004.

23. Belcaro G, Cornelli U, Luzzi R, Cesarone M, Dugall M, Feragalli B, Errichi S, Ippolito E, Grossi M, Hosoi M, Cornelli M, Gizzi G. Pycnogenol® Supplementation Improves Health Risk Factors in Subjects With Metabolic Syndrome. Phytotherapy Research. October 2013.

24. Zibadi S, Rohdewald P, Park D, Watson R. Reduction of Cardiovascular Risk Factors in Subjects With Type 2 Diabetes by Pycnogenol® Supplementation. Nutrition Research. April 2008.

25. Liu X, Wei J, Tan F, Zhou S, Würthwein G, Rohdewald P. Antidiabetic Effect of Pycnogenol® French Maritime Pine Bark Extract in Patients With Diabetes Type II. Life Sciences. October 2004.


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